Have a look at the thread Page 7 in the link below. Apart from the settings there ia also a Registry edit that will reset to manual updates only with no nag pop-up. Please note ZoneLabs warnings contained in the thread.
See that at the very end of current page there is an indication from ZA that because of the large amount of negative response they are going to remove the mandatory pop ups and allow checks to be turned off. They say this may happen in a couple of weeks
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