CPU is a great bit of kit , I have mine overclocked to 4.5GHz with a liquid cooler . Personally I would go for an ASUS Z77 Sabertooth MoBo , but I don't know what your budget is . The graphics on the CPU are not really suitable for modern games . You would be much better off getting a discreet GPU , again budget is your limiting factor , as well as case size and PSU output .
HTC U12 Plus review: Hands-on