For me, a dual monitor setup is essential. I use my PC similarly to you and the ability to have e.g. Chrome open on one monitor and Word open on another is essential. Yes, you could have both open on a single larger screen, but I don't think it would be nearly as effective. I hear you on the cable clutter thing, though - but in my mind, it's a price will worth paying.
HTC U12 Plus review: Hands-on