Creating a System Restore point (as well as your Registry backup) before you make any changes should be sufficient.
However temporarily removing and reinstalling hardware or software first will almost certainly guarantee a System Restore point - I've found that just creating a System Restore point doesn't always mean it will work, especially if you have made no changes.
I can manage my own problems, but when giving advice over the phone to friends and family, or on this Forum, I need a safe Plan "B"
Before recommending REGEDIT to anyone, I want to know the best way of restoring when things go wrong, because that (Plan "B") seems a necessary part of any advice offerred to others whatever version of Windows they are using.
There may not be a one answer suits all, but accepting that Regedit is a powerful tool only occasionally needed, what is a sensible recovery method if damaged?