Do you have a disc with the drivers on it?
sounds like lack of twain drivers or a service not started
" Epson scan Release Date: 13-Jul-2018 File Format: EXE File Size: 0.72 MBs Additional Information Issue:
Since updating to the new version of Window 10 (April update) Epson Scan will not launch or will freeze indefinitely after launching, using Preview or pressing the scan button.
To resolve this issue we have released an updated driver or patch dependent on your Epson product."