Hi. Whenever I've needed to run an .iso format program, I've normally used CD Drive emulation software, such as Daemon Tools, which is generally held in high regard, and I personally reccomend. Download it here: click here
What it does is creates a virtual CD/DVD Drive - That is to say, an extra CD Drive will show up in 'My Computer' even though you won't have one physically installed on your PC. What you do is mount the .iso image to the CD Drive, and voila! That virtual drive acts as though you've put in your flight simulation game disc. As it runs from the hard drive, load times are generally better.
Of course, you can also use your Power ISO software to burn the .iso image to a blank CD/DVD, and it will be just like a normal game on CD.