On a working computer, make a DVD or 4GB+ USB Flash Install with W10 Media Creation Tool. (use "For another PC option")
Boot and re-install W10 to C:\
All Apps and Programs will need to be reinstalled. Folders and Files are retained in c:\windows.old
Scan with Malwarebytes Free when done.
If problems or evidence of infection continue, repeat the Install but delete C:\ when asked "Where do you want to install Windows?"
Backup anything important first
You may need to fiddle around in the BIOS/UEFI to get DVD or Flash to boot before the Hard Drive.