most of these so called 'speed up' programs just cause you more problems and i would tend to leave most of them alone.
click here says 'restore a backup by clicking on "Menu", "SettingFreeze" in the main window of WinSpeedUp' use add remove programs to uninstall it.
my favorites, that have never gave me any problems are:
cleanup click here (use on standard settings and click 'cleanup' then restart)
ccleaner click here (delete anything it finds)
adaware click here (update it after install and delete all it finds)
spybot search and destroy click here (as adaware)
spywareblaster click here (makes adaware ans spybots job easier, update it and click 'enable all protection)
if you want to try a registry cleaner try regseeker click here (click 'clean the registry' tick all boxes and click ok)