The only thing to keep an eye on is any cooling fans you may have.Being mechanical,and revolving at high speed, they have a finite life.If possible I would set my computer to give an audible warning if the cpu or case temperature started to rise.
There is a company near here, I do a bit of I.T. work for.
They have a 486 dx 75 running windows 3.1 with a 540Mb hard drive. This, apart from power failures, has never been switched off. They can not remember exactly when it was installed but they think about 1995. It just ticks over and does the wages for the workforce.:-)
most PC's / servers in industry remain are up-and-running 24/7 so you have no worries there. As for your laptop though, not sure there as these were never designed for that type of thing - - -maybe OK .