if you uninstall the programs in safe mode they should not be running and uninstall ok.
some programs though are just downright lazy when it comes to saying goodbye to them.its usually just a matter of as Lozzy says above using explorer and deleting the program or log file in C:\programs etc.you can also remove traces from the registry which most programs leave behind:
click start/run and type regedit and click ok.click my computer and back up the registry first by clicking file/export and save as type.reg anywhere convienient,next click edit/find and type the name of the program or developer and click ok.delete anything it finds by right clicking the entry and selecting delete.
tap F3 after deleting each entry and the search will continue,as above delete all untill it is finished searching the registry.
if it all goes wrong, which im sure it wont just click on the backup file you saved to restore the reg.