Though I do not doubt you I personally have never come across software that did not allow me to put it where I wanted. But I also have SSD's in all my PC's (3)and just use them for the OS and programs with plenty of free space still available even though I have a least 50 programs installed. I only have 128GB which I have found is more than enough for my needs.
But I do move all the My folders moved to a bigger drive as soon as I have installed the OS and all games go to yet another hdd.
Could you post what programs you are having difficulty with? and I will look at them tomorrow when I am back at my desktop.