You'll have to bear with me on this one. I don't play computer games and the PC in question is my son's, thus description provided is second hand.
So, gaming PC, Windows 10 Home OS, MSI A58M-E33 motherboard. 8Gb RAM, 2Tb HDD. Came with an AMD Radeon 7 graphics card attached to MB. We installed a MSI GeForce GTX750Ti.
For some time he has complained of the PC crashing and blue screening while playing online games. We even had it upgraded by the manufacturer, but the problem persisited. He concluded it was too sick to use, but, after a period of abstinence announed it was working again. He went to reinstall his games, but at some time in the process the PC crashed and the following message appeared on a black screen "Reboot and Select proper Boot device or Insert Boot Media in selected Boot device and press a key..." [eccentric use of capitals verbatim]. I have looked at the BIOS and it should be trying to boot from the hard drive. I updated the BIOS and, as I was doing so, the BIOS gave me two options to update, but would only allow the update to be applied to one. The BIOS flash was successful. I then updated all the drivers from the MSI website for the graphics card and all things motherboard related. I then went to the AMD website and while using their utility to find the best driver for the Radeon 7 (which ran forever!) it crashed again and the aforementioned message appeared. My son thinks it's a hardware problem, but everything is protected by UPS, so I'm not so sure.