How did you try to amend your home page. The safest way is to go to the surf to the page you want then go to Tools > Options and use the <Use Current> button. I suggest you then close down IE and see if it holds when you start it up again. If it does, then try rebooting. This will help identify where you are loosing the setting (I doubt its anything malicious - you are at least defaulting to a safe page).