Don't know which is *best* and you give no details of Operating System, programs involved - or whether is is a home setup or what..
Why don't you try one or two ways of doing it by burning one DVD until you have developed your own prefered way that works on your set up?
If it was me I would organise the files into folders that fit onto a DVD and also save an ISO file of each folder for ease of storage which would then give me the option to burn a new disc at any future date. I would also have the ISO on the pc that I was using to burn.
I usually burn at a lower rate as I have found that to be more reliable.