S-ATA is probably not worth it, at least not yet. 133mbps versus 150mbps - not much in it really, and I have read that S-ATA doesn't really achieve the full 150 here in the real world, just as 133 doesn't often give 100%, so don't feel like you're missing out. You may want to consider S-ATA if you plan to use two or more disks, perhaps in a RAID arrangement. click here is your first stop for more info. click here is aslo worth a read.