Many years ago I waas given a Microsoft "Natural" keyboard - the one with a curved layout. After an hour or so learning how to use it, I wouldn't now be without it. Far less cramp in the fingers and wrists using this.
As for a mouse, I use a MS "Intellimouse Explorer" which I go free with my copy of Office XP.
Neither of these are wireless - just reliable.
Regarding nicotine stains, the only way to avoid them is to stop smoking but, you know that already, don't you. Try!!