cannot locate cd rom

hi, just tried some games on vista, all ok, but when i close the game there is a window saying 'cannot locate cd rom'? i have had a look around and can only find this problem on xp, the games work ok, i just wondered what this new niggle is and if i can resolve it. thanks.
it was fine this morning, no changes have been made, kaspersky reports all clear, as does avgas, even did a scan with defender, none found any problems.

a reboot seems to have sorted it.

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