Get it fired up, think about tweeks and adjustments once you have experienced Vista as it is oroginally intended.
There are plenty of tips and tweeks and this site can help you if you think there are things you would like to change.
From start up the strong thing I would recommend is to go through the crap ware which some PC manufacturers put on and ditch things you do not need or like.
The other thing is much of the crap ware sets itself up to lauch at boot thereby slowing up your PC. To control this there is a useful facility in the Control Panel to deal with many but not all programs which start at boot. the main way to control startup programs is click here