Appleseed the original cell animé is a shoddy bit of crap usually picked up by teens because it's got rude words in. The signs are all spelt incorrectly and the names of the characters from the original Manga were changed. I'm surprised Masamune Shirow put his name to it.
The new one is full CGI 3D rendered and is absolutely stunning. It's nearly as good to look at as Ghost in the shell two, but is somewhat less into psycho babble type navel gazing on the nature of the soul. May well be the best animé yet made.