...make a system restore point first. Some such utilities will do this for you, but it's safe to be prudent. Next, look carefully at the info given about these ticked items - do they have names similar to useful programs you have? Are they in categories such as 'malware' or 'threat'?
This will help you decide to remove or not. Finally, as a rule of thumb, programs designed to remove malware etc. will mark only those things known to be bad! After taking this into consideration, go ahead and remove them! You can always revert to the restore point if something is wrong.