It is not something that I have tried.
Presumably you are using frames to group option buttons. You can also assign option buttons to groups. This allows buttons to act as if they were in a frame, without the frame. Only one button in a group can be active at a time. To assign buttons to a group, right click on each option button and select Properties. Then assign a unique name for each set of buttons in the group name property.
You could then try adding a frame around that group and another set of option buttons.