The box has a tiltle, "StartupMonitor Warning" That is all it says. I don't know what it is but it only has two options, Yes to allow the program to run or No to stop it. I've been clicking the No button but it keeps coming back, twice while I've been typing this, in fact.
Well it's not a threat, but a program looking for updates for the InstallShield program, so you could allow it. That would stop the box popping up. The box is part of one of your security programs informing you that a application wishes to be added to the startup menu in case it's a threat. Personally I'd allow it, but it's up to you.
Have a look in your start up folders or do a search for isuspm* and see if this finds a shortcut which you could delete or re-name temporarily to see if that is the culprit. If you re-name, you may get a win message saying that it can't find whatever you named it to but you will then know the culprit.get