Not THE Ozzy Osbourne? I have been using Tweakvi for a week or so now, although I have not tried to uninstall it...when you say your folders were wiped out...you mean you can't see them? Uninstalling the software would normally force a re-set of any tweaks you had previously used.
I have only used it to remove certain icons, and appearence settings. Did you backup your registry when you first used it? If so, it may be possible to restore it, although I would suggest that you may be to far down the road now that you have installed other software. You could try system restore, I think this may be a registry issue though.