When I reported a problem regarding installing a third party software I was told by Help desk to delete all the folders in the "C:\Documents and Settings\username\Local Settings\Temp" in Windows 2000 and XP).
I am reluctant to do this as I am not sure if this is a wise suggestion .
All Temp files should be safe to delete, that's why they are called "Temp". However I would be reluctant to say that they are ALWAYS safe to delete because it's just possible that some careless software writer has put something important there. Much safer is to make a copy of the contents into a folder of your making, or even to a CD or USP flash drive before deleting them, then if there is a problem you can put the files back.