Try Winaso registry optimizer free or trial version it only cleans 10 items at a time but you can run it as often as you like.It also has a registry Defrag on it which is handy and also does an automatic back up when you run it.I have never needed to use it.Initially it will probably find over 100 problems But when you have finished running it you will find your computer runs faster,I also use C Cleaner which also does a good job,Use one one week the other the next,A tip with C Cleaner it will delete all cookies,Unless you go into its cookie folder and save the ones that you want to keep,The cookies that you want to keep put in the right hand side box,the ones that you don't want keep them in the left box,I would recommend both Cleaners and both free.
just downloaded them as per C.48s entry above, thought i would show results.
wise disk cleaner = fisrt ran AWC2 AND CCLEANER to clear rubbish then ran wise disk cleaner it found a further 19mb of rubbish after scanning on default settings.
wise registry cleaner = first ran AWC2 again which threw up 112 reg entries after the clean of wise disk cleaner, had AWC2 fix these, then ran ccleaner, eusing, and winaso. after they had cleaned ran wise reg cleaner it found 113 entries but showed nearly all of them unsafe to delete leaving about a dozen to delete one of which is a false safe to delete re hp printer software [winaso also throws this one up] i deleted the keys shown safe to delete all seems ok.