Are the keyboard and mouse connected to USB or PS2 ports? If they are USB can you get into the BIOS to check if Legacy USB Option is enabled. This is usually found under the Integrated Peripherals section of the BIOS.
Thanks I'll check tomorrow, (so hacked off I had to leave it)
mate suggested the HDD's may be infected (which they were recently) again to the extent they wont let me back in after changes? I dont understand why the second machine is like this though, only borrowed the mouse and returned it? (Windows ggrrrrrrrrr)