I am running Windows 98SE and OE 6. Recently I am finding OE will not keep its settings. When it stops I look at Tool/Acoounts to find the Mail and SMTP settings have been replace by 127.0.0.1 which is the number reserved for your own computer - so I am told. If I reset the Account then it works for a short while then reverts again. It has been suggested it might be the Virus checker - I am riunning Avast or the Firewall- I am running Outpost.
A third possibility was a Trojan. I have scanned with A squared and there was indeed a Trojan which was quarantined but OE is STILL doing it.