I have just bought a new computer with Vista on it. I have installed Kaspersky AV and Comodo firewall. Do I need any other protection? I had SpyBot S&D, AdaWare, C Cleaner and Registry Mechanic on my old XP machine.
You have more than adequate protection. AdAware, in it's latest version can conflict with whole time protectors. Vista has much inbuilt security and your biggest sercurity tool is you and your own common sense when surfing.
If you want a good scanner for irregular use then try the free Superantispyware.
CCleaner works perfectly with Vista and as I found out does as much as Reg mechanic in practical terms.
I used to run a number of programs like you but now only use Windows Live One Care and CCleaner.