Is it a cordless mouse? Check the batteries first.
Then try the following for both corded and cordless.
Use Control Panel Add/Remove Programs to remove all references to Genius Mouse.
Open Device Manager by right clicking My computer, then click on Properties, Hardware Device Manager.
Click on + Mice and other pointing devices to show the mouse you have installed.
Right click and then Uninstall
Reboot computer to allow Windows to find your mouse and if necessary install the new driver from your CD or file when you get the New Hardware Found message.