Right, I have an Logitech MX500 USB mouse and have been using the thumb buttons to control actions in games. However I recently bought a USB hub and plugged it into this, the mouse was redetected and installed by the PC. However when I went to play a game the buttons stopped working. Tried to reconfigure them in game with no success, the scroll wheel and left right buttons still work though. Tried using the mouse back in the old USB port, reinstalling the software and tried it on some other games, still the buttons arent being recognised in game. Whats gone wrong?!