For the second part of your question, I think it is the icon in the taskbar that you refer to as flashing orange. If this is the case it is because OE has opened but is not selected for some reason (anti-malware?). If you look at OE the frame colour is faded which means it isn`t selected; if you click on OE the frame colour will harden and the flashing will stop - clicking on the taskbar has the same effect.
For the first part of your question, it sounds as if something is blocking the page. Are you running an Add-on such as NoScript, a pop-up blocker or a setting that protects against infection? These may prevent the clicking of content.