"Please Note: Safe Run Mode doesn't work with Microsoft Windows XP x64, and works with limitations on Microsoft Windows Vista x64 and Microsoft Windows 7 x64. " they are basically covering themselves. you may experience crashes to desktop, or system hang, however you shouldn't. Same with avast and pretty much everything, possible exception is latest version of sandboxie. amazes me that they still write new products for 32 bit systems with the time 64 bit has been out. The problem is caused because you are not running a 64 bit program.
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