I don't use these programs but I would guess you would be better installing the Antispyware part too, in order to deal with spywhare. Also it might not be a good idea to put all your eggs in one basket with spyware programs so to speak, one could miss what another picks up. I use F-Secure internet security, SuperAntispyware (free), Malwarebytes (free) and SpywareBlaster (free) along with Vista Defender on a regular basis. Maybe this is overkill but I'm happy and that's what counts.
These programs play together well with my setup but may not work on yours. One thing I should add is only have one Antivirus package on your system, you will run into problems if you have more installed.