Asuming Malwre bytes paid for version as you need a realtime scanner
Get rid of Spybot and AdAware they are both Mal / spyware scanners.
You still need Avast as a Virus scanner
and ZoneAlarm as your firewall
Back up your MAlware bytes with Superantispyware and use SpywareBlaster as a blocker and you are well covered.
Or replace the lot with MS essentials