I have no idea. Bearing in mind what happened when they brought XP out I would think that there is a good possability that you might have a problem with some of them. If there are problems then there will be patches created for some of the games but its early days yet. Thats one of the reasons I will be waiting for some time, worries about some programs not running, games mainly, and the availability of patches if needed.
Hopefully someone who has tried it will give you a definative answer.