I have used Chrome since the first release and I am very happy with it. I also have the latest Firefox and IE8 but use Chrome as my default as it is much faster to load than either of the others. Yes there are still one or two sites that require IE but they are getting fewer.
I find the Chrome interface much less cluttered than Firefox or IE and being able to "rip" tabs onto and off new pages can be useful when you want to see pages side by side.
I have been using Chrome. Clean and fast, my only criticism is that there is no way to clear your browsing history automatically as you can with Firefox. It can be done manually(if you remember to) however.