I have never tried there anti-virus.I always use programs that come recommended,I use Avg and to tell the truth I did not know that Comodo had an anti-virus program.I have never heard anyone mention it before,The old saying ,better the devil you know,comes to mind.
I gave it a couple of months on my system and I like the ideas it has, with the HIPS thing, but there are still a few bugs that need to be ironed out. The system for sending in files to be put on the Comodo "safelist" is a good idea, but in reality the amount of data it wanted to upload was prohibitive.
I've ended up uninstalling it and putting AVG back on.
Once they release the full release of it, I'll probably use it.
But everyone should use their Firewall as it is very good (unless you're on Vista!)
Avast is a good anti virus program . click here I never got on with Avg and when i used to scan with Belarac it used to say my virus definitions are out of date. Comodo firewall i have heard of but not their anti virus .