With the modern switching power supplies which rely on static sensitive semiconductors rather than the old transformer/rectifier systems, I would think it quite possible that damage could be caused in that way.
yes i myself have seen power supplies take out most of a PCs components
but i spose the what im really asking is -"is it likely that a single incident of ESD can render all the parts of a pc inoperable" meaning is it likely that this can result in all the drives ceasing to function along with memory cpu and the power supply?
Assuming we not not considering lightning strikes but just, say, friction static, one destroyed device may then malfunction in a different way (overcurrent, overvoltage) and the sequence than prograss like that. The initiating destroyed semiconductor could be anywhere in the system.