Or just block third party cookies on IE6 to do it automatically.
Further to this there is nothing top fear from cookies.
The Domain Blocker is just a simplified version of Spyware Blaster. It inserts "kill-bits" into the registry in the same way Spyware Blaster does.
Advantage of Spyware Blaster is you get to check and download updates easily. And you can easily reverse its effects if for any reason you want to without having to know how to do it manually yin the registry.