Haven't heard of AMD processors being incompatible with software before. I run an AthlonXP1800 no problems. If you use the search facility you will find lots of threads on this subject. I even posted the same question myself last year when i was looking to build my own PC. Personally i find that AMD offers better value for money. Lots more power per pound sterling. It's down to your own budget and instinct at the end of the day.