A new version of Nod came out only yesterday, version 3.0. They also do a security suite which I am now running. It's seems excellent, just like the older version except it's now much more user friendly. As ever it doesn't seem to impact on the performance of pc at all, unlike many other anti-virus programs. If you are willing to pay, I personally don't think you can beat nod.
I can't comment on kapersky however as I have never used it. There are however a number of free anti-virus solutions around which do a fair job too, I use avast! and AVG on 2 of my other pcs and they seem to do okay.