Some of the reviews talk of half an hour to set it up. Mine is taking much longer than that to get it just the way I want. Not complaining, though - it's a fascinating piece of technology. Every time I use it, I see a little bit of fine tuning needed.
My advice would be to only set up the minimum of devices first, for example, the TV and set top tuner. Then one touch of a screen icon will turn them both on and tune to your favourite channel.
Once that Activity is running smoothly, with all the buttons doing what they're supposed to do, start adding more devices.