CSC workers, who are members of Unite the union, will be protesting tomorrow over the company's compulsory redundancy plans.
The redundancies affect staff working on the delivery of the Lorenzo-based electronic patient record system under the NHS's failed, £12.7 billion National Programme for IT (NPfIT).
Although it pledged at the time to minimise compulsory cuts, by redeploying some staff and offering others a voluntary redundancy package, Unite said that after several weeks of consultation, CSC was insisting on issuing compulsory redundancy notices despite receiving a "sufficient" number of volunteer requests to leave the company.
Kevin O'Gallagher, Unite national officer, said: "We will now increase pressure on CSC to listen to its staff and to Unite's proposals. We have put forward a detailed plan which will avoid any compulsory redundancies in the company.
"However, these plans have fallen on deaf ears. Our members are now taking to the streets to get their voice heard."
Staff at CSC's sites in Chesterfield, Chorley, Leeds and Solihull will take part in the protest between 1pm and 2pm tomorrow.
CSC's new CEO Mike Lawrie recently said that he believes the troubled business 'can be fixed', despite facing significant challenges including the unresolved contractual negotiations with the NHS.
Meanwhile, a senior MP slammed the Ministry of Defence's (MoD) decision to chose CSC over HP and Capita to provide it with payroll and personnel services, labelling it as "regrettable" given the supplier's performance on the NHS contract.